PPI
Have you or a loved one suffered from a kidney injury after taking Nexium, Prilosec, or Previcid? You may be entitled to compensation.
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The Nexium and Prilosec lawsuits claim that proton pump inhibitors cause an increased risk of kidney and renal failure. As of October 2018, more than 2,300 lawsuits have been filed in federal court against the manufacturers of Nexium & Prilosec.
More than 4,000 lawsuits have been filed against the manufacturers of Nexium and Prilosec by individuals who have suffered injuries as a result of taking these two proton pump inhibitor (PPI) medications. The lawsuits are presently combined before a federal judge in New Jersey where all of the national discovery and evidence gathering is taking place.
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The manufacturers of Nexium and Prilosec failed to warn doctors and patients that use of its medication could cause kidney and renal failure, including acute interstitial nephritis (AIN).
In the court filings, lawyers argue the following:
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The most serious potential side effects caused through the use of Nexium & Prilosec are strokes, bone fractures, acute kidney injury (AKI), renal failure, and heart damage.
People who take multiple daily doses for a long period of time (a year or longer), especially those 50 years of age or older, have an increased risk of fractures of the hip, wrist, and spine. Additionally, people who use the drugs appear to have a 20-50% higher risk of chronic kidney disease compared with nonusers, and a 20-30% increased risk for stroke.
Nexium and Prilosec users "are at increased risk for heart attack, stroke and renal failure,” says Dr. John P. Cooke, Houston Methodist Research Institute.
It’s very important to tell your doctor if you experience any of the following problems: (i) kidney disease; (ii) osteoporosis; (iii) low bone mineral density (osteopenia); (iv) numbness in the face, arm or leg; (v) confusion or trouble speaking; (vi) loss of vision; (vii) dizziness; (viii) difficulty walking; (ix) severe headache; or (x) low levels of magnesium in your blood.
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According to a large clinical trial called PLOS ONE, the use of Nexium and other PPIs has been associated with an estimated increase in heart attack risk of 16-21%. These drugs can reduce the production of a substance that protects blood vessels. The internal lining of the vessels is then damaged, increasing the formation of dangerous blood clots and other cardiovascular diseases.
PPIs are linked with a 20 to 50 percent higher risk of chronic kidney disease (CKD), as demonstrated by a large study published in the JAMA Internal Medicine journal. The risk is higher in patients who took higher doses of these medications. CKD causes a gradual loss of kidney function that may also lead to renal failure.
Symptoms of CKD include: (1) buildup of fluid in the lungs; (2) difficulty urinating; (3) electrolyte imbalances; (4) extreme fatigue; (5) heartbeat abnormalities; (6) high blood pressure; (7) nausea, vomiting or loss of appetite; and (8) swelling in the legs, ankles or feet.
An ischemic stroke occurs when the flow of blood and oxygen to the brain is reduced, causing the brain cells and tissue to die. PPIs are linked to a 20-30% increased risk of strokes depending upon the dosage the person is taking per day.
Nexium and Prilosec do more than just reduce gastric acid, they also reduce the secretion of several other substances produced by stomach cells. These specific substances are required for the proper absorption of important nutrients such as Vitamin C, Vitamin B12, calcium, and magnesium.
Long-term use of PPIs has been associated with iron deficiency anemia, hypomagnesemia, and pernicious anemia. The use of PPIs for extended periods may also reduce bone strength, increasing the risk of hip, spine, and wrist fractures.
PPIs also indirectly increase the production of other substances such as gastrin. Hypergastrinemia has been associated with an increased risk of gastric tumors as well as with other cancer malignancies in patients affected by gastroesophageal reflux disease (GERD).
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Proper gastric acid secretion is critical to our health. PPIs reduce acid secretion by up to 99%, which is much more than is usually required by most patients, especially if these drugs are taken for extended periods of time.
Hydrochloric acid is, in fact, a barrier to sterilize the food we eat, killing most microbes such as bacteria and viruses. Without stomach acid, patients are at a greater risk of serious infections including Clostridium difficile enteritis, diarrhea, and pneumonia.
A study published in the journal JAMA Neurology showed that regular use of PPIs was linked with a 50% increased risk of dementia in elderly patients. Researchers analyzed data from 74,000 patients over a period of 7 years, and explained that in those countries where PPIs are available as over-the-counter medications (such as the United States), the risk may be even higher.
We are representing individuals who have suffered kidney or renal injuries as a result of using Nexium or Prilosec. If you have experienced these injuries, then we will be seeking the following damages for you:
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